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Article

Splicing program of human MENA produces a previously undescribed isoform associated with invasive, mesenchymal-like breast tumors.

Proceedings of the National Academy of Sciences of the United States of America - 20 Nov 2012

Di Modugno Francesca, Iapicca Pierluigi, Boudreau Aaron, Mottolese Marcella, Terrenato Irene, Perracchio Letizia, Carstens Russ P, Santoni Angela, Bissell Mina J, Nisticò Paola

Abstract excerpt

Human mena (hMENA), a member of the actin cytoskeleton regulators Ena/VASP, is overexpressed in high-risk preneoplastic lesions and in primary breast tumors and has been identified as playing a role in invasiveness and poor prognosis in breast cancers that express HER2. Here we identify a unique...

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Source

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Identifiers

PMID: 23129656
DOI: 10.1073/pnas.1214394109
PMCID: PMC3511125

Genes

MET
VASP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23129656-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Splicing program of human MENA produces a previously undescribed isoform associated with invasive, mesenchymal-like breast tumors.PMID 23129656Read ↗

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