Article

Short-term statin treatment reduces, and long-term statin treatment abolishes chronic vascular injury by radiation therapy

2023-09-22

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The incidental use of statins during radiation therapy has been associated with a reduced long-term risk of developing atherosclerotic cardiovascular disease. <h4>Objectives</h4> Determine if irradiation causes chronic vascular injury and whether short-term administration of statins during and after irradiation is sufficient to prevent chronic injury compared to long-term a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0a343742-44bb-5adb-8bc2-a2214dcb3cf5
DOI: 10.1101/2023.09.20.558723

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Short-term statin treatment reduces, and long-term statin treatment abolishes chronic vascular injury by radiation therapyDOI 10.1101/2023.09.20.558723Read

Pathological effects of ionizing radiation: endothelial activation and dysfunctionSemantic proximity Read

Multiple exposures to low-dose ionizing radiation induced the initiation and progression of pro-atherosclerotic phenotypes in mice and vascular endothelial cell damage.Semantic proximity Read

Ionizing radiation and atherosclerosis: current knowledge and future challenges.Semantic proximity Read

DNA damage response in vascular endothelial senescence: Implication for radiation-induced cardiovascular diseasesSemantic proximity Read

Ionizing radiation accelerates the development of atherosclerotic lesions in ApoE-/- mice and predisposes to an inflammatory plaque phenotype prone to hemorrhage.Semantic proximity Read

PPARα Is Necessary for Radiation-Induced Activation of Noncanonical TGFβ Signaling in the Heart.Semantic proximity Read

Metallothionein 2 activation by pravastatin reinforces epithelial integrity and ameliorates radiation-induced enteropathySemantic proximity Read

Role of TGF Beta and PPAR Alpha Signaling Pathways in Radiation Response of Locally Exposed Heart: Integrated Global Transcriptomics and Proteomics AnalysisSemantic proximity Read

Radiation-Induced Macrophage Senescence Impairs Resolution Programs and Drives Cardiovascular InflammationSemantic proximity Read

Statins are potential anticancerous agents (Review)Semantic proximity Read

[Role of endothelium in radiation-induced normal tissue damages].Semantic proximity Read

MicroRNAs as Potential Mediators for Cigarette Smoking Induced AtherosclerosisSemantic proximity Read