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Article

PPARα Is Necessary for Radiation-Induced Activation of Noncanonical TGFβ Signaling in the Heart.

Journal of proteome research - 6 Apr 2018

Subramanian Vikram, Borchard Sabine, Azimzadeh Omid, Sievert Wolfgang, Merl-Pham Juliane, Mancuso Mariateresa, Pasquali Emanuela, Multhoff Gabriele, Popper Bastian, Zischka Hans, Atkinson Michael J, Tapio Soile

Abstract excerpt

High-dose ionizing radiation is known to induce adverse effects such as inflammation and fibrosis in the heart. Transcriptional regulators PPARα and TGFβ are known to be involved in this radiation response. PPARα, an anti-inflammatory transcription factor controlling cardiac energy metabolism, is inactivated by irradiation. The pro-inflammatory and pro-fibrotic TGFβ is activated by irradiation via SMAD-dependent...

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PMID: 29560722
DOI: 10.1021/acs.jproteome.8b00001

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