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Article

Multiple exposures to low-dose ionizing radiation induced the initiation and progression of pro-atherosclerotic phenotypes in mice and vascular endothelial cell damage.

Science progress - 1 Jan 2024

Liu Meng-Meng, Ding Chun-Yan, Li Zhi-Hui, Yi Ru-Han, Ma Li-Ping, Ou Xiang-Ming, Liu Hai-Xiang, Gao Ling, Liu Qing-Jie

Abstract excerpt

OBJECTIVE: This study aimed to investigate the effects of low-dose radiation on the abdominal aorta of mice and vascular endothelial cells. METHODS: Wild-type and tumor-bearing mice were exposed to 15 sessions of low-dose irradiation, resulting in cumulative radiation doses of 187.5, 375, and 750 mGy. The effect on the cardiovascular system was assessed. Immunohistochemistry analyzed protein expressions of...

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Identifiers

PMID: 38385346
DOI: 10.1177/00368504241228668
PMCID: PMC10893836

Genes

H2AX
IL6

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