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DNA damage response in vascular endothelial senescence: Implication for radiation-induced cardiovascular diseases

29 Mar 2021

Abstract excerpt

A post-exposure cohort study in Hiroshima and Nagasaki reported that low-dose exposure to radiation heightened the risk of cardiovascular diseases (CVD), such as stroke and myocardial infarction, by 14-18% per Gy. Moreover, the risk of atherosclerosis in the coronary arteries reportedly increases with radiation therapy of the chest, including breast and lung cancer treatment. Cellular senescence of vascular...

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PMID: 33912932
DOI: 10.1093/jrr/rrab032

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