Article
Mitochondrial complex I deficiency stratifies idiopathic Parkinson's disease.
Nature communications - 29 Apr 2024
Flønes Irene H, Toker Lilah, Sandnes Dagny Ann, Castelli Martina, Mostafavi Sepideh, Lura Njål, Shadad Omnia, Fernandez-Vizarra Erika, Painous Cèlia, Pérez-Soriano Alexandra, Compta Yaroslau, Molina-Porcel Laura, Alves Guido, Tysnes Ole-Bjørn, Dölle Christian, Nido Gonzalo S, Tzoulis Charalampos
Abstract excerpt
Idiopathic Parkinson's disease (iPD) is believed to have a heterogeneous pathophysiology, but molecular disease subtypes have not been identified. Here, we show that iPD can be stratified according to the severity of neuronal respiratory complex I (CI) deficiency, and identify two emerging disease subtypes with distinct molecular and clinical profiles. The CI deficient (CI-PD) subtype accounts for approximately a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.