Article

Mitochondrial complex I deficiency stratifies idiopathic Parkinson’s disease

2023-09-22

Abstract excerpt

Idiopathic Parkinson’s disease (iPD) is believed to have a heterogeneous pathophysiology, but molecular disease subtypes have not been identified. Here, we show that iPD can be stratified according to the severity of neuronal respiratory complex I (CI) deficiency, and identify two emerging disease subtypes with distinct molecular and clinical profiles. The CI deficient (CI-PD) subtype accounts for approximately a...

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Literature Corpus work: bc521666-f994-5233-b412-d8d93f8110e2
DOI: 10.1101/2023.09.22.558615

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