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Engineered heat-stable variants of <i>Trypanosoma cruzi</i> flagellar protein Tc24 enable serological detection of Chagas disease

2025-08-23

Abstract excerpt

<h4>ABSTRACT</h4> Chagas disease, caused by the protozoan Trypanosoma cruzi , is one of the major neglected diseases globally, killing 12,000 people per year and silently infecting an estimated 7 million people worldwide. Current diagnostic methods are limited by cost, complexity and cold-chain requirements. The T. cruzi flagellar protein Tc24 is a promising antigen for serological tests but suffers of poor sol...

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Literature Corpus work
09f934be-89bd-53a6-afdb-66011f5ab8d2
DOI
10.1101/2025.08.23.671862
Open publication

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Engineered heat-stable variants of <i>Trypanosoma cruzi</i> flagellar protein Tc24 enable serological detection of Chagas diseaseDOI 10.1101/2025.08.23.671862
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