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Impact of Inactivation Methods on Biosafety and Antigen Reactivity of <i>Brucella melitensis</i> from the Perspective of Astral-DIA Proteomics Based on Antibody Immunoprecipitation Mass Spectrometry

2025-07-28

Abstract excerpt

Effective Brucella inactivation is imperative for safe vaccine development, diagnostics, and sample handling, particularly in resource-limited regions lacking high-level containment facilities. This study investigated inactivation methods using the Rev.1 vaccine strain and three Brucella melitensis field isolates from Gansu (GS-XG, GS-SN, GS-MQ). Heat (80°C/95°C, 10-20 min) and formaldehyde (0.4%/0.6%, 48-72 h)...

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Literature Corpus work
3f6f95c5-1ddc-52dc-bfb2-24c7058c0186
DOI
10.1101/2025.07.28.667132
Open publication

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Impact of Inactivation Methods on Biosafety and Antigen Reactivity of <i>Brucella melitensis</i> from the Perspective of Astral-DIA Proteomics Based on Antibody Immunoprecipitation Mass SpectrometryDOI 10.1101/2025.07.28.667132
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