Article

Aryl hydrocarbon receptor (AHR) and IL-13 signaling crosstalk in human keratinocytes and atopic dermatitis

2023-06-21

Abstract excerpt

Atopic dermatitis (AD) is an allergic skin disease mediated by skin barrier impairment and IL-13-driven immune response. Activation of the aryl hydrocarbon receptor (AHR) has shown promise in early clinical trials for AD, however, the mechanism by which AHR mediates this function is unknown. Herein, AHR signaling is shown to be dysregulated in AD patients using publicly available gene expression data from biopsies...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 09f5a3c6-3dbd-5d65-9bbf-d200c2c7f409
DOI: 10.1101/2023.06.17.545291

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Aryl hydrocarbon receptor (AHR) and IL-13 signaling crosstalk in human keratinocytes and atopic dermatitisDOI 10.1101/2023.06.17.545291Read

AHR and NRF2 in Skin Homeostasis and Atopic DermatitisSemantic proximity Read

Aryl Hydrocarbon Receptor in Atopic Dermatitis and Psoriasis.Semantic proximity Read

MicroRNA-203 ameliorates skin inflammation in atopic dermatitis by suppressing mast cell hyperactivation via upregulating aryl hydrocarbon receptor signalingSemantic proximity Read

The AhR-Ovol1-Id1 regulatory axis in keratinocytes promotes epidermal and immune homeostasis in atopic dermatitis-like skin inflammationSemantic proximity Read

An AhR-Ovol1-Id1 regulatory axis in keratinocytes promotes skin homeostasis against atopic dermatitisSemantic proximity Read

Transcriptomic Profiling of Lesional and Perilesional Skin in Atopic Dermatitis Suggests Barrier Dysfunction, Inflammatory Activation, and Alterations to Vitamin D MetabolismSemantic proximity Read

Transcriptomic Profiling of Lesional and Perilesional Skin in Atopic Dermatitis Suggests Barrier Dysfunction, Inflammatory Activation, and Alterations to Vitamin D MetabolismSemantic proximity Read

Multiple Transcriptome Data Analysis Reveals Biologically Relevant Atopic Dermatitis Signature Genes and PathwaysSemantic proximity Read

The aryl hydrocarbon receptor regulates epidermal differentiation through transient activation of TFAP2ASemantic proximity Read

Role of Aryl Hydrocarbon Receptor Activation in Inflammatory Chronic Skin DiseasesSemantic proximity Read

Transcriptomic Analysis Links Eosinophilic Esophagitis and Atopic DermatitisSemantic proximity Read

Genome-Wide Integration of Genetic and Genomic Studies of Atopic Dermatitis: Insights into Genetic Architecture and Pathogenesis.Semantic proximity Read