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Transcriptomic Profiling of Lesional and Perilesional Skin in Atopic Dermatitis Suggests Barrier Dysfunction, Inflammatory Activation, and Alterations to Vitamin D Metabolism

2025-05-13

Abstract excerpt

Atopic dermatitis (AD) is a chronic inflammatory skin disease marked by impaired barrier func-tion and immune dysregulation. This study explores transcriptomic differences between lesional (IL) and perilesional (PL) skin in patient with AD, focusing on barrier-related and vitamin D–associated pathways. RNA sequencing was performed on matched IL and PL biopsies from 21 adults with moderate-to-severe AD. Diffe...

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Literature Corpus work
968e7dfb-c4dd-58c7-b7bd-6f4d7822ac9a
DOI
10.20944/preprints202505.0865.v1
Open publication

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Transcriptomic Profiling of Lesional and Perilesional Skin in Atopic Dermatitis Suggests Barrier Dysfunction, Inflammatory Activation, and Alterations to Vitamin D MetabolismDOI 10.20944/preprints202505.0865.v1
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