Article

An AhR-Ovol1-Id1 regulatory axis in keratinocytes promotes skin homeostasis against atopic dermatitis

2024-01-31

Abstract excerpt

<h4>ABSTRACT</h4> Skin is our outer permeability and immune defense barrier against myriad external assaults. Aryl hydrocarbon receptor (AhR) senses environmental factors and regulates barrier robustness and immune homeostasis. AhR agonist is in clinical trial for atopic dermatitis (AD) treatment, but the underlying mechanism of action remains ill-defined. Here we report OVOL1/Ovol1 as a conserved and direct tra...

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Literature Corpus work: 6924ba4b-3e51-5151-8d31-6e5e1fd2c4a7
DOI: 10.1101/2024.01.29.577821

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