Article

Identifying and targeting abnormal mitochondrial localization associated with psychosis

2025-10-08

Abstract excerpt

Therapeutics working by novel mechanisms are needed for patients with psychiatric conditions. Cell-based assays to identify candidates that reverse observed abnormalities could accelerate the process. Here, we imaged peripheral cells (skin fibroblasts) of 168 patients, stained for DNA, actin, and mitochondria. We found mitochondria tend to be farther from the cell border for patients who experience psychosis (incl...

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Literature Corpus work: 09f3084e-c886-5b57-a688-7f842f94fb23
DOI: 10.1101/2025.10.08.676630

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