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Mucosal immune stimulation with HSV-2 and polyICLC boosts control of viremia in SIVΔNef vaccinated rhesus macaques with breakthrough SIV infection

2020-06-02

Abstract excerpt

<h4>ABSTRACT</h4> Development of an effective human immunodeficiency virus (HIV) vaccine is among the highest priorities in the biomedical research agenda. Adjuvants enhance vaccine efficacy, but in the case of HIV, strong or inappropriate immune activation may undermine protection by increasing HIV susceptibility. Co-infection with immunomodulatory pathogens may also impact vaccine efficacy. In the rhesus macaqu...

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Literature Corpus work
09b777ce-95c7-512d-96d5-07f3460421b4
DOI
10.1101/2020.06.02.129494
Open publication

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Mucosal immune stimulation with HSV-2 and polyICLC boosts control of viremia in SIVΔNef vaccinated rhesus macaques with breakthrough SIV infectionDOI 10.1101/2020.06.02.129494
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