Combination Adenovirus and Protein Vaccines Prevent Infection or Reduce Viral Burden after Heterologous Clade C Simian-Human Immunodeficiency Virus Mucosal Challenge.

doi:10.1128/JVI.01092-17

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Article

Combination Adenovirus and Protein Vaccines Prevent Infection or Reduce Viral Burden after Heterologous Clade C Simian-Human Immunodeficiency Virus Mucosal Challenge.

Journal of virology - 15 Jan 2018

Malherbe Delphine C, Mendy Jason, Vang Lo, Barnette Philip T, Reed Jason, Lakhashe Samir K, Owuor Joshua, Gach Johannes S, Legasse Alfred W, Axthelm Michael K, LaBranche Celia C, Montefiori David, Forthal Donald N, Park Byung, Wilson James M, McLinden James H, Xiang Jinhua, Stapleton Jack T, Sacha Jonah B, Haynes Barton F, Liao Hua-Xin, Ruprecht Ruth M, Smith Jonathan, Gurwith Marc, Haigwood Nancy L, Alexander Jeff

Abstract excerpt

HIV vaccine development is focused on designing immunogens and delivery methods that elicit protective immunity. We evaluated a combination of adenovirus (Ad) vectors expressing HIV 1086.C (clade C) envelope glycoprotein (Env), SIV Gag p55, and human pegivirus GBV-C E2 glycoprotein. We compared replicating simian (SAd7) with nonreplicating human (Ad4) adenovirus-vectored vaccines paired with recombinant proteins...

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PMID: 29093095
DOI: 10.1128/JVI.01092-17
PMCID: PMC5752948

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