Article
Rectal HSV-2 Infection May Increase Rectal SIV Acquisition Even in the Context of SIVΔnef Vaccination.
PloS one - 1 Jan 2016
Guerra-Pérez Natalia, Aravantinou Meropi, Veglia Filippo, Goode Diana, Truong Rosaline, Derby Nina, Blanchard James, Grasperge Brooke, Gettie Agegnehu, Robbiani Melissa, Martinelli Elena
Abstract excerpt
Prevalent HSV-2 infection increases the risk of HIV acquisition both in men and women even in asymptomatic subjects. Understanding the impact of HSV-2 on the mucosal microenvironment may help to identify determinants of susceptibility to HIV. Vaginal HSV-2 infection increases the frequency of cells highly susceptible to HIV in the vaginal tissue of women and macaques and this correlates with increased...
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