Article

Loss of Stathmin-2, a hallmark of TDP-43-associated ALS, causes motor neuropathy

2022-03-14

Abstract excerpt

<h4>Summary</h4> TDP-43 mediates proper Stathmin-2 (STMN2) mRNA splicing, and STMN2 protein is reduced in the spinal cord of most ALS patients. To test the hypothesis that STMN2 loss contributes to ALS pathogenesis, we generated constitutive and conditional STMN2 knockout mice. Constitutive STMN2 loss results in early-onset sensory and motor neuropathy featuring impaired motor behavior and dramatic distal neuromu...

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Literature Corpus work: 09b6f2d6-6189-57b9-ba37-0fb5fe212830
DOI: 10.1101/2022.03.13.484188

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