Article

Reduced STMN2 and pathogenic TDP-43, two hallmarks of ALS, synergize to accelerate motor decline in mice

2024-03-20

Abstract excerpt

Pathological TDP-43 loss from the nucleus and cytoplasmic aggregation occurs in almost all cases of ALS and half of frontotemporal dementia patients. Stathmin2 ( Stmn2) is a key target of TDP-43 regulation and aberrantly spliced Stmn2 mRNA is found in patients with ALS, frontotemporal dementia, and Alzheimer’s Disease. STMN2 participates in the axon injury response and its depletion in vivo partially replicate...

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Literature Corpus work: 852d1fee-ef54-513b-b0d8-fc5bbf489a09
DOI: 10.1101/2024.03.19.585052

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