Article

Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation

2022-12-12

Abstract excerpt

The human mRNA most affected by TDP-43 loss-of-function is transcribed from the STMN2 gene and encodes stathmin-2 (also known as SCG10), whose loss is a neurodegenerative disease hallmark. Here using multiple in vivo approaches, including transient antisense oligonucleotide (ASO)-mediated suppression, chronic shRNA-mediated depletion in aging mice, and germline deletion, we establish stathmin-2 to be essential f...

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Literature Corpus work: 4986f8de-ae86-5f0a-9f00-9add3878349c
DOI: 10.1101/2022.12.11.519794

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