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Article

Stathmin-deficient mice develop an age-dependent axonopathy of the central and peripheral nervous systems.

The American journal of pathology - 1 Feb 2002

Liedtke Wolfgang, Leman Elizabeth E, Fyffe Robert E W, Raine Cedric S, Schubart Ulrich K

Abstract excerpt

Stathmin is a cytosolic protein that binds tubulin and destabilizes cellular microtubules, an activity regulated by phosphorylation. Despite its abundant expression in the developing mammalian nervous system and despite its high degree of evolutionary conservation, stathmin-deficient mice do not exhibit a developmental phenotype.(1) Here we report that aging stathmin(-/-) mice develop an axonopathy of the central...

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Identifiers

PMID: 11839567
DOI: 10.1016/S0002-9440(10)64866-3
PMCID: PMC1850667

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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