Article
Investigating the Impact of Different Acrylamide (Electrophilic Warhead) on Osimertinib's Pharmacological Spectrum by Molecular Mechanic and Quantum Mechanic Approach.
Combinatorial chemistry & high throughput screening - 1 Jan 2022
Patel Harun, Ahmad Iqrar, Jadhav Harsha, Pawara Rahul, Lokwani Deepak, Surana Sanjay
Abstract excerpt
BACKGROUND: Lung cancer has become the prominent cause of the cancer-related deaths globally. More than 80 % of all lung cancers have been diagnosed with Non- Small Cell Lung Cancer (NSCLC). The USFDA approved osimertinib to treat patients with metastatic T790M EGFR NSCLC on a regular basis in March 2017. Recently, C797S mutation to osimertinib has been reported, which indicates the need for structural...
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