Antibodies to Intercellular Adhesion Molecule 1-Binding Plasmodium falciparum Erythrocyte Membrane Protein 1-DBLβ Are Biomarkers of Protective Immunity to Malaria in a Cohort of Young Children from Papua New Guinea.

doi:10.1128/IAI.00485-17

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Antibodies to Intercellular Adhesion Molecule 1-Binding Plasmodium falciparum Erythrocyte Membrane Protein 1-DBLβ Are Biomarkers of Protective Immunity to Malaria in a Cohort of Young Children from Papua New Guinea.

Infection and immunity - 1 Aug 2018

Tessema Sofonias K, Utama Digjaya, Chesnokov Olga, Hodder Anthony N, Lin Clara S, Harrison G L Abby, Jespersen Jakob S, Petersen Bent, Tavul Livingstone, Siba Peter, Kwiatkowski Dominic, Lavstsen Thomas, Hansen Diana S, Oleinikov Andrew V, Mueller Ivo, Barry Alyssa E

Abstract excerpt

Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) mediates parasite sequestration to the cerebral microvasculature via binding of DBLβ domains to intercellular adhesion molecule 1 (ICAM1) and is associated with severe cerebral malaria. In a cohort of 187 young children from Papua New Guinea (PNG), we examined baseline levels of antibody to the ICAM1-binding PfEMP1 domain, DBLβ3PF11_0521, in comparison...

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PMID: 29784862
DOI: 10.1128/IAI.00485-17
PMCID: PMC6056858

Genes

ICAM1
NTS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Antibodies to Intercellular Adhesion Molecule 1-Binding Plasmodium falciparum Erythrocyte Membrane Protein 1-DBLβ Are Biomarkers of Protective Immunity to Malaria in a Cohort of Young Children from Papua New Guinea.PMID 29784862Read ↗

Protective immunity against severe malaria is associated with antibodies to a conserved repertoire of PfEMP1 variantsSemantic proximity Read ↗

High Throughput Functional Assays of the Variant Antigen PfEMP1 Reveal a Single Domain in the 3D7 Plasmodium falciparum Genome that Binds ICAM1 with High Affinity and Is Targeted by Naturally Acquired Neutralizing AntibodiesSemantic proximity Read ↗

Acquisition of IgG to ICAM-1-Binding DBLβ Domains in the Plasmodium falciparum Erythrocyte Membrane Protein 1 Antigen Family Varies between Groups A, B, and CSemantic proximity Read ↗

A Plasma Survey Using 38 PfEMP1 Domains Reveals Frequent Recognition of the Plasmodium falciparum Antigen VAR2CSA among Young Tanzanian ChildrenSemantic proximity Read ↗

Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral MalariaSemantic proximity Read ↗

Identification of a <i>Plasmodium falciparum</i> intercellular adhesion molecule-1 binding domain: A parasite adhesion trait implicated in cerebral malariaSemantic proximity Read ↗

Protective Immunity against Severe Malaria in Children Is Associated with a Limited Repertoire of Antibodies to Conserved PfEMP1 VariantsSemantic proximity Read ↗

High plasma levels of soluble intercellular adhesion molecule (ICAM)-1 are associated with cerebral malaria.Semantic proximity Read ↗

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Neutrophils impose strong selective pressure against PfEMP1 variants implicated in cerebral malariaSemantic proximity Read ↗

Structural conservation despite huge sequence diversity allows EPCR binding by the PfEMP1 family implicated in severe childhood malaria.Semantic proximity Read ↗

Profiles of global mutations in the human intercellular adhesion molecule-1 (ICAM-1) shed light on population-specific malaria susceptibility.Semantic proximity Read ↗

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