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Article

COA6 Facilitates Cytochrome c Oxidase Biogenesis as Thiol-reductase for Copper Metallochaperones in Mitochondria.

Journal of molecular biology - 27 Mar 2020

Pacheu-Grau David, Wasilewski Michał, Oeljeklaus Silke, Gibhardt Christine Silvia, Aich Abhishek, Chudenkova Margarita, Dennerlein Sven, Deckers Markus, Bogeski Ivan, Warscheid Bettina, Chacinska Agnieszka, Rehling Peter

Abstract excerpt

The mitochondrial cytochrome c oxidase, the terminal enzyme of the respiratory chain, contains heme and copper centers for electron transfer. The conserved COX2 subunit contains the CuA site, a binuclear copper center. The copper chaperones SCO1, SCO2, and COA6, are required for CuA center formation. Loss of function of these chaperones and the concomitant cytochrome c oxidase deficiency cause severe human...

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Identifiers

PMID: 32061935
DOI: 10.1016/j.jmb.2020.01.036
PMCID: PMC7254062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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COA6 Facilitates Cytochrome c Oxidase Biogenesis as Thiol-reductase for Copper Metallochaperones in Mitochondria.PMID 32061935Read ↗

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