Article

LoRTIA Plus: a chemistry-agnostic, feature-first software package for long-read transcriptome annotation

2026-04-04

Abstract excerpt

Long-read RNA sequencing (lrRNA-seq) enables direct reconstruction of full-length transcripts, yet existing annotation tools show variable performance across genomes and library chemistries, particularly for novel isoforms. We present LoRTIA Plus, a chemistry-agnostic suite for transcriptome annotation and reconstruction from lrRNA-seq data. LoRTIA Plus first detects and filters transcription start sites (TSSs), t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 093bd9e9-526d-5ea7-b02c-27b9af5ac9d9
DOI: 10.64898/2026.04.03.716279

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

LoRTIA Plus: a chemistry-agnostic, feature-first software package for long-read transcriptome annotationDOI 10.64898/2026.04.03.716279Read

Facilitating genome annotation using ANNEXA and long-read RNA sequencingSemantic proximity Read

High-density resolution of the Kaposi's sarcoma associated herpesvirus transcriptome identifies novel transcript isoforms generated by long-range transcription and alternative splicingSemantic proximity Read

Systematic assessment of long-read RNA-seq methods for transcript identification and quantificationSemantic proximity Read

A systematic benchmark of Nanopore long read RNA sequencing for transcript level analysis in human cell linesSemantic proximity Read

Accurate strand-specific long-read transcript isoform discovery and quantification at bulk, single-cell, and single-nucleus resolutionSemantic proximity Read

Nanopore Guided Annotation of Transcriptome ArchitecturesSemantic proximity Read

Benchmarking long-read RNA-sequencing technologies with <i>LongBench:</i> a cross-platform reference dataset profiling cancer cell lines with bulk and single-cell approachesSemantic proximity Read

CLASS: Accurate and Efficient Splice Variant Annotation from RNA-seq ReadsSemantic proximity Read

A technology-agnostic long-read analysis pipeline for transcriptome discovery and quantificationSemantic proximity Read

Genome-wide identification of transcript start and end sites by transcript isoform sequencing.Semantic proximity Read

RNA BaseCode: Long-Read RNA Sequences with Short-Read AccuracySemantic proximity Read

The ENCODE4 long-read RNA-seq collection reveals distinct classes of transcript structure diversitySemantic proximity Read