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Immunization with a recombinant ASP-2/Transialidase chimeric protein induces robust protective immunity in both murine and canine models of Chagas’ disease

2022-06-27

Abstract excerpt

<title>Abstract</title> <p>We have systematically shown that the Amastigote Surface Protein-2 (ASP-2) and Transialidase (TS) antigens either in the form of recombinant protein or encoded in the plasmids and human adenovirus 5 (hAd5) confer strong protection against different lineages of Trypanosoma cruzi parasites. Herein we generated a chimeric protein containing the most immunogenic regions for T and B cells fr...

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Identifiers and source

Literature Corpus work
093265bb-5177-584c-9ab5-f9220c1aa5e3
DOI
10.21203/rs.3.rs-1735149/v1
Open publication

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Immunization with a recombinant ASP-2/Transialidase chimeric protein induces robust protective immunity in both murine and canine models of Chagas’ diseaseDOI 10.21203/rs.3.rs-1735149/v1
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