Article
Vaccination using recombinants influenza and adenoviruses encoding amastigote surface protein-2 are highly effective on protection against Trypanosoma cruzi infection.
PloS one - 1 Jan 2013
Barbosa Rafael Polidoro Alves, Filho Bruno Galvão, Dos Santos Luara Isabela, Junior Policarpo Ademar Sales, Marques Pedro Elias, Pereira Rafaela Vaz Sousa, Cara Denise Carmona, Bruña-Romero Oscar, Rodrigues Maurício Martins, Gazzinelli Ricardo Tostes, Machado Alexandre Vieira
Abstract excerpt
In the present study we evaluated the protection raised by immunization with recombinant influenza viruses carrying sequences coding for polypeptides corresponding to medial and carboxi-terminal moieties of Trypanosoma cruzi ´s amastigote surface protein 2 (ASP2). Those viruses were used in sequential immunization with recombinant adenovirus (heterologous prime-boost immunization protocol) encoding the complete...
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