New Vaccine Formulations Containing a Modified Version of the Amastigote 2 Antigen and the Non-Virulent Trypanosoma cruzi CL-14 Strain Are Highly Antigenic and Protective against Leishmania infantum Challenge

Abstract excerpt

Visceral leishmaniasis (VL) is a major public health issue reported as the second illness in mortality amongst all tropical diseases. Clinical trials have shown that protection against VL is associated with robust T cell responses, especially those producing IFN-γ. The Leishmania A2 protein has been repeatedly described as immunogenic and protective against VL in different animal models; it is recognized by human...

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