Article

Prototypical pacemaker neurons are immunocompetent cells

2019-08-30

Abstract excerpt

Pacemaker neurons exert control over neuronal circuit function by their intrinsic ability to generate rhythmic bursts of action potential. Recent work has identified rhythmic gut contractions in human, mice and hydra to be dependent on both neurons and the resident microbiota. However, little is known about the evolutionary origin of these neurons and their interaction with microbes. In this study, we identified a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 090aaeb9-3536-552f-962b-1ace8f50b74e
DOI: 10.1101/750026

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Prototypical pacemaker neurons are immunocompetent cellsDOI 10.1101/750026Read

Prototypical pacemaker neurons interact with the resident microbiotaSemantic proximity Read

Optogenetics-integrated gut organ culture system connects enteric neurons dynamics and gut homeostasisSemantic proximity Read

The enteric nervous system of the human and mouse colon at a single-cell resolutionSemantic proximity Read

Healthy Intestinal Function Relies on Coordinated Enteric Nervous System, Immune System, and Epithelium ResponsesSemantic proximity Read

Mature tuft cell phenotypes are sequentially expressed along the intestinal crypt-villus axis following cytokine-induced tuft cell hyperplasiaSemantic proximity Read

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System AxisSemantic proximity Read

Single-Soma Deep RNA Sequencing of Human Dorsal Root Ganglion Neurons Reveals Novel Molecular and Cellular Mechanisms Underlying SomatosensationSemantic proximity Read

Gut-innervating nociceptor neurons protect against enteric infection by modulating the microbiota and Peyer’s patch microfold cellsSemantic proximity Read

Leveraging deep single-soma RNA sequencing to explore the neural basis of human somatosensationSemantic proximity Read

Intestinal neuron-associated macrophages in health and diseaseSemantic proximity Read

Identification and Analysis of Putative Homologues of Mechanosensitive Channels in Pathogenic ProtozoaSemantic proximity Read

Molecular Signaling and Dysfunction of the Human Reactive Enteric Glial Cell Phenotype: Implications for GI Infection, IBD, POI, Neurological, Motility, and GI Disorders.Semantic proximity Read