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<i>Streptococcus pyogenes</i> SpyCEP: a chemokine‐inactivating protease with unique structural and biochemical features

25 Mar 2010

Abstract excerpt

ABSTRACT SpyCEP is a 170‐kDa multidomain serine protease expressed on the surface of the human pathogen Streptococcus pyogenes , which plays an important role in infection by catalyzing cleavage and inactivation of the neutrophil chemoatractant interleukin‐8. In this study, we investigated the biochemical features and maturation process of SpyCEP, starting from a recombinant form of the protease expressed and...

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PMID: 20339024
DOI: 10.1096/fj.09-145631

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