Article
Porphyromonas gingivalis Type IX Secretion Substrates Are Cleaved and Modified by a Sortase-Like Mechanism.
PLoS pathogens - 1 Sept 2015
Gorasia Dhana G, Veith Paul D, Chen Dina, Seers Christine A, Mitchell Helen A, Chen Yu-Yen, Glew Michelle D, Dashper Stuart G, Reynolds Eric C
Abstract excerpt
The type IX secretion system (T9SS) of Porphyromonas gingivalis secretes proteins possessing a conserved C-terminal domain (CTD) to the cell surface. The C-terminal signal is essential for these proteins to translocate across the outer membrane via the T9SS. On the surface the CTD of these proteins is cleaved prior to extensive glycosylation. It is believed that the modification on these CTD proteins is anionic...
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