Article
Gene copy number variation spanning 60 million years of human and primate evolution.
Genome research - 1 Sept 2007
Dumas Laura, Kim Young H, Karimpour-Fard Anis, Cox Michael, Hopkins Janet, Pollack Jonathan R, Sikela James M
Abstract excerpt
Given the evolutionary importance of gene duplication to the emergence of species-specific traits, we have extended the application of cDNA array-based comparative genomic hybridization (aCGH) to survey gene duplications and losses genome-wide across 10 primate species, including human. Using human cDNA arrays that contained 41,126 cDNAs, corresponding to 24,473 unique human genes, we identified 4159 genes that...
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