Article

Using CRISPR/Cas9 to investigate the role of candidate human disease gene orthologs in Ciona

2026-08-11

Abstract excerpt

<h4>ABSTRACT</h4> The tunicate Ciona robusta offers a tractable non-vertebrate chordate model for probing gene function via tissue-specific, CRISPR/Cas9-mediated mutagenesis in F0. Building on Arcadia Science’s Zoogle platform, which identifies and ranks orthologs of human genes from various non-traditional model organisms, we carried out a pilot project to probe the developmental roles of three notochord- and e...

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Literature Corpus work: 08f3c66e-b70a-5d2f-9e75-2e53d6aa237d
DOI: 10.64898/2026.08.10.743552

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