Article

CRISPR/Cas9 targeting Ttc30a mimics ciliary chondrodysplasia with polycystic kidney disease

2020-11-27

Abstract excerpt

Skeletal ciliopathies (e.g. Jeune syndrome, short rib polydactyly syndrome, Sensenbrenner syndrome) are frequently associated with cystic kidney disease and other organ manifestations, but a common molecular mechanism has remained elusive. We established two models for skeletal ciliopathies ( ift80 and ift172 ) in Xenopus tropicalis , which exhibited severe limb deformities, polydactyly, cystic kidneys, and cil...

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Literature Corpus work: 9e1b13ce-293f-509e-a860-ed604e112410
DOI: 10.1101/2020.11.27.400994

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