Their loss is our gain: regressive evolution in vertebrates provides genomic models for uncovering human disease loci.

doi:10.1136/jmedgenet-2017-104837

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Article

Their loss is our gain: regressive evolution in vertebrates provides genomic models for uncovering human disease loci.

Journal of medical genetics - 1 Dec 2017

Emerling Christopher A, Widjaja Andrew D, Nguyen Nancy N, Springer Mark S

Abstract excerpt

Throughout Earth's history, evolution's numerous natural 'experiments' have resulted in a diverse range of phenotypes. Though de novo phenotypes receive widespread attention, degeneration of traits inherited from an ancestor is a very common, yet frequently neglected, evolutionary path. The latter phenomenon, known as regressive evolution, often results in vertebrates with phenotypes that mimic inherited disease...

Topics

Amelogenesis Imperfecta
Animals
Color Vision Defects
Evolution, Molecular
Genetic Association Studies
Genetic Loci
Genetic Predisposition to Disease
Genome
Genomics
Humans
Models, Genetic
Mutation
Phenotype
Pseudogenes
Vertebrates

Source

Open in PubMed

Identifiers

PMID: 28814606
DOI: 10.1136/jmedgenet-2017-104837

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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