Article
Using Zebrafish to Test the Genetic Basis of Human Craniofacial Diseases.
Journal of dental research - 1 Oct 2017
Machado R Grecco, Eames B Frank
Abstract excerpt
Genome-wide association studies (GWASs) opened an innovative and productive avenue to investigate the molecular basis of human craniofacial disease. However, GWASs identify candidate genes only; they do not prove that any particular one is the functional villain underlying disease or just an unlucky genomic bystander. Genetic manipulation of animal models is the best approach to reveal which genetic loci...
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