Article

ARID1A deficiency unleashes centromeric RNA transcription to drive chromosomal instability and boosts PKMYT1 inhibitor efficacy via RNA sensing

2026-04-13

Abstract excerpt

Cancer gene-associated mutations and molecular hallmarks of chromosomal instability (CIN) are unexpectedly common in histologically normal cells and tissues. These emerging findings challenge the binary distinction between “normal” and “cancerous” cells and suggest that early tumorigenesis may commence against a background of widespread yet largely tolerated genomic instability. However, it remains largely unexplo...

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Literature Corpus work: 08b73f42-b18e-5b34-abbf-407b50085886
DOI: 10.64898/2026.04.11.717899

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