Article

Permutational immune analysis reveals architectural similarities between inflammaging, Down syndrome and autoimmunity

2021-09-15

Abstract excerpt

People with Down syndrome show cellular and clinical features of dysregulated aging of the immune system, including naïve-memory shift in the T cell compartment and increased incidence of autoimmunity. However, a quantitative understanding of how various immune compartments change with age in Down syndrome remains lacking. Here we performed deep immunophenotyping of a cohort of individuals with Down syndrome acros...

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Literature Corpus work: 0887bde3-b51c-5822-9db8-1d4b98f4ceeb
DOI: 10.1101/2021.09.13.460115

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