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Progressive deterioration of adaptive immune repertoires in Down syndrome linked to interferon hyperactivity and lymphoid tissue disorganization

2026-08-04

Abstract excerpt

<h4>ABSTRACT</h4> Persons with Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), display strong dysregulation of adaptive immunity, which underlies high risk of complications from infections, widespread autoimmunity, and poor vaccine responses. However, the mechanisms by which T21 dysregulates adaptive immunity across the lifespan remain poorly understood. We report here a multimodal analysis...

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Literature Corpus work
4f2271f4-bb84-5db8-9b22-106e0a7fa44a
DOI
10.64898/2026.07.30.741516
Open publication

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