JAK inhibition decreases the autoimmune burden in Down syndrome

Abstract excerpt

Individuals with Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), display clear signs of immune dysregulation, including high rates of autoimmune disorders and severe complications from infections. Although it is well established that T21 causes increased interferon responses and JAK/STAT signaling, elevated autoantibodies, global immune remodeling, and hypercytokinemia, the interplay between...

Topics

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• Autoimmunity
• Cytokines
• Down Syndrome
• Down syndrome and intellectual disability research
• Immune System
• Immunodeficiency and Autoimmune Disorders
• Phenotype
• Receptors, Interferon

Identifiers and source

Literature Corpus work

4f58885d-83ba-52f6-b6f0-0a39db8bd9ce

DOI

10.1101/2024.06.13.24308783