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Article

HSP40 proteins use class-specific regulation to drive HSP70 functional diversity.

Nature - 1 Nov 2020

Faust Ofrah, Abayev-Avraham Meital, Wentink Anne S, Maurer Michael, Nillegoda Nadinath B, London Nir, Bukau Bernd, Rosenzweig Rina

Abstract excerpt

The ubiquitous heat shock protein 70 (HSP70) family consists of ATP-dependent molecular chaperones, which perform numerous cellular functions that affect almost all aspects of the protein life cycle from synthesis to degradation1-3. Achieving this broad spectrum of functions requires precise regulation of HSP70 activity. Proteins of the HSP40 family, also known as J-domain proteins (JDPs), have a key role in this...

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Identifiers

PMID: 33177718
DOI: 10.1038/s41586-020-2906-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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