Article
Toll-like receptor 3: involvement with exogenous and endogenous RNA.
International reviews of immunology - 1 Dec 2010
Amarante Marla Karine, Watanabe Maria Angelica Ehara
Abstract excerpt
The recognition of pathogens is assigned to an evolutionarily conserved family of receptors, the Toll-like receptors (TLRs). The investigation of RNA-based immunology has been reinvigorated with the observation that TLR3s interact with RNA (dsRNA of viral origin, poly (I:C) and endogenous RNA). Many RNAs, therefore, join the list of endogenous ligands for TLRs. The further finding that nucleoside modification...
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