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Exonic Disruption Facilitates Antiviral CRISPR-Cas9 Activity for Multistrain HIV-1 Elimination

2021-01-14

Abstract excerpt

A barrier to HIV-1 cure rests in the persistence of proviral DNA in infected CD4+ leukocytes. The high mutation rate of HIV-1 gives rise to numerous circulating strains with increased capacity for immune evasion and antiretroviral drug resistance. To facilitate viral elimination while accounting for this diversity, we propose genetic inactivation of proviral DNA with CRISPR-spCas9. We designed a library of “mosaic...

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Identifiers and source

Literature Corpus work
32908722-592d-5c0a-baed-15908e3527a0
DOI
10.1101/2021.01.14.426544
Open publication

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Exonic Disruption Facilitates Antiviral CRISPR-Cas9 Activity for Multistrain HIV-1 EliminationDOI 10.1101/2021.01.14.426544
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