Mutational landscape of pure ductal carcinoma in situ and associations with disease prognosis and response to radiotherapy

doi:10.1186/s13058-025-02080-z

Article

Mutational landscape of pure ductal carcinoma in situ and associations with disease prognosis and response to radiotherapy

8 Jul 2025

Abstract excerpt

BACKGROUND: Managing Ductal Carcinoma in Situ (DCIS) remains challenging due to the lack of reliable biomarkers to predict radiotherapy (RT) response, leading to both overtreatment of indolent disease and undertreatment of aggressive cases. RESULTS: Through whole-exome sequencing of 147 DCIS cases, we characterized the genomic landscape of pure DCIS and identified genetic alterations associated with the risk of...

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.