Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Amyotrophic lateral sclerosis: an update on recent genetic insights.

Journal of neurology - 1 Nov 2013

Iguchi Yohei, Katsuno Masahisa, Ikenaka Kensuke, Ishigaki Shinsuke, Sobue Gen

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease affecting both upper and lower motor neurons. The prognosis for ALS is extremely poor, but there is a limited course of treatment with only one approved medication. A most striking recent discovery is that TDP-43 is identified as a key molecule that is associated with both sporadic and familial forms of ALS. TDP-43 is not only a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Transcription Factor TFIIIA
Share to Ataxins
Share to Autophagy-Related Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to C9orf72 Protein

Share to Flavoproteins

Share to Profilins

Share to RNA-Binding Protein FUS

Share to Valosin Containing Protein

Source

Identifiers

PMID: 24085347
DOI: 10.1007/s00415-013-7112-y

Genes

EWSR1
FIG4
FUS
OPTN
SQSTM1
TAF15
UBQLN2
VCP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Amyotrophic lateral sclerosis: an update on recent genetic insights.PMID 24085347Read ↗

Recent Updates on the Genetics of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.Semantic proximity Read ↗

The genetics and neuropathology of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Progress in Amyotrophic Lateral Sclerosis Gene DiscoverySemantic proximity Read ↗

The Overlapping Genetics of Amyotrophic Lateral Sclerosis and Frontotemporal DementiaSemantic proximity Read ↗

Amyotrophic lateral sclerosis.Semantic proximity Read ↗

Pathogenic Genome Signatures That Damage Motor Neurons in Amyotrophic Lateral Sclerosis.Semantic proximity Read ↗

Implications of miRNAs dysregulation in amyotrophic lateral sclerosis: Challenging for clinical applicationsSemantic proximity Read ↗

Amyotrophic Lateral Sclerosis and Other Motor Neuron DiseasesSemantic proximity Read ↗

State of play in amyotrophic lateral sclerosis genetics.Semantic proximity Read ↗

Connecting RNA-Modifying Similarities of TDP-43, FUS, and SOD1 with MicroRNA Dysregulation Amidst A Renewed Network Perspective of Amyotrophic Lateral Sclerosis Proteinopathy.Semantic proximity Read ↗

Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degenerations: Similarities in Genetic BackgroundSemantic proximity Read ↗

TARDBP and FUS mutations associated with amyotrophic lateral sclerosis: summary and update.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.