Article

3’UTR variants of ALS-linked RNAs modify subcellular and cellular phenotypes

2025-04-05

Abstract excerpt

While most human genes express mRNA 3’untranslated region (3’UTR) variants of different lengths, their impact on cell physiology and disease remains largely unknown. Here, we studied 3’UTR length heterogeneity in amyotrophic lateral sclerosis (ALS) and determined that three ALS-linked transcripts exhibit lengthening of their 3’UTRs in patient samples. We investigated phenotypical effects in a neuronal cell line ex...

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Literature Corpus work: ac68a1be-9bb7-5d18-a6db-10cba494681d
DOI: 10.1101/2025.04.05.647382

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