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FOXA1 phosphorylation by CDK4 prevents activation of novel chromatin regions and HER2 expression in breast cancer

2023-03-15

Abstract excerpt

<title>Abstract</title> <p>The use of Cyclin Dependent Kinase 4/6 inhibitors (CDK4/6i) induce transcription in breast tumors. The control mechanism of such genomic changes and their physiological relevance are not elucidated yet. Now, we identified chromatin activation of tumors treated with CDK4/6i. These chromatin changes induce an increase of HER2 expression and signaling. Mechanically, we demonstrate that CDK...

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Literature Corpus work
07d86495-7622-5774-850b-e02e61884ebd
DOI
10.21203/rs.3.rs-2659889/v1
Open publication

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FOXA1 phosphorylation by CDK4 prevents activation of novel chromatin regions and HER2 expression in breast cancerDOI 10.21203/rs.3.rs-2659889/v1
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