Alcohol-related liver disease disrupts bile acid synthesis and is associated with compensatory gut microbiota changes

Abstract excerpt

<h4>Background</h4> Alcohol overuse disrupts liver function and alters microbial gut communities, with alcohol-related liver disease (ALD) accounting for half of all liver-related deaths worldwide. Bile acids (BAs) regulate liver and gut function, but their metabolism becomes disrupted in ALD. While it is known that gut microbes transform primary to secondary BAs, which are subsequently reabsorbed via the enteroh...

Topics

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• Alcohol Consumption and Health Effects
• Alcoholism and Thiamine Deficiency
• Bile Acids and Salts
• Diet and metabolism studies
• Drug Transport and Resistance Mechanisms
• Gut microbiota and health
• Liver Disease and Transplantation
• Liver Disease Diagnosis and Treatment

Identifiers and source

Literature Corpus work

07d2eafc-8878-516c-8c8c-df1080abf6f8

DOI

10.1101/2025.07.23.25332046