Integrated multi-matrix bile acid metabolic metrics (BAMMs): A methodological framework for functional metabolic phenotyping in human subjects.

Abstract excerpt

Traditional single-matrix bile acid (BA) analysis, which typically relies on a limited set of analytes in plasma or feces, often fails to capture the compartmentalized complexity of the microbiome-gut-liver axis. To address this, we developed a high-coverage, 61-analyte metabolomics platform integrated via a multifaceted Bile Acid Metabolic Metrics (BAMMs) framework across plasma, urine, and feces. In a 12-week...

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• Bile Acids and Salts
• Feces
• Metabolomics
• Phenotype