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Antiviral Peptides as Promising Therapeutics against SARS-CoV-2

23 Oct 2020

Abstract excerpt

Over 50 peptides, which were known to inhibit SARS-CoV-1, were computationally screened against the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2. Based on the binding affinity and interaction, 15 peptides were selected, which showed higher affinity compared to the α-helix of the human ACE2 receptor. Molecular dynamics simulation demonstrated that two peptides, S2P25 and S2P26, were the most...

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PMID: 33095007
DOI: 10.1021/acs.jpcb.0c05621

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