Article

The β-amyloid oligomer Aβ*56 is associated with Alzheimer’s dementia independently of amyloid pathology

2025-04-11

Abstract excerpt

The amyloid cascade hypothesis posits that β-amyloid (Aβ) oligomers (Aβo) play a key role in the pathogenesis of Alzheimer’s disease (AD). Aβo are believed to contribute to dementia in AD, and more than a dozen have been identified. While some oligomers are associated with amyloid plaques, others—such as Aβ*56—are not. It remains unclear whether these plaque-independent oligomers contribute to dementia. Aβ*56 is a...

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Literature Corpus work: 07b1ae8c-ab02-5ffe-a997-d2be6b8e7043
DOI: 10.1101/2025.04.11.648457

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